The marker for this mission will not appear right away after finishing the previous mission, so feel free to explore until you get a phone call from Reggie.
Reggie begins the mission saying there was a huge explosion reported on the news that was since retracted, so he wants you to check things out. Head to the marker on your map to officially start the mission, where you will need to go to the Waterfront to investigate. When you get there, you find the place has been torched and you decide to take a picture to show to Reggie.
After taking the picture, some DUPs will show up, so take them out and then pick up the helmet nearby to learn that Hank is still alive. More DUPs will show up now, so get rid of them and then there will be another photo opportunity nearby. It is at this point that Fetch chimes in and says someone is nearby smoking out DUP choppers.
Head to the marker to meet up with Fetch, who decides to sit this one out. Now, go to the roof where Hank is said to be and when you get there, he will start running away. Chase after him until he stops on a roof with some DUP Agents, so take out a couple and Hank will get away again. Thankfully, Reggie knows where he’s at, so head there and another chase will begin. Keep going until a cutscene occurs and the mission will end after some dialog.
It’s a good idea, if you haven’t already, to upgrade the Smoke and Video powers before starting the next mission. Specifically, you’ll want to upgrade the Quick Drain, as well as the ammo capacity for the R1 abilities.