Available: From the point where you join the College.
Locate and speak to Sergius the Enchanter. He asks you to help bring the item to enchant to him. He always gives you a random NPC and a random location, so just go to this NPC, retrieve the item and return to Sergius to receive some gold for your efforts. That’s it.
I happened to find an interesting glitch while doing this quest. I was supposed to go get some gear to be enchanted from a guy named Aicantar in Markarth. Problem was, he was in Calcelmo’s Tower, and for the life of me I COULD NOT talk to him without getting told that I wasn’t supposed to be there (I could NOT do this quest at ALL). ALSO, I got the thieves guild quest "Hard Answers" for a SECOND TIME when I entered the Dwemer Museum! Lesson: SAVE before taking quests from Sergius.