There are 300 optional missions in Crisis Core Final Fantasy VII: Reunion. The Hojo’s Laboratory category (M5) features battles against various Hojo Experiments but all of them are not available right away. This page will tell you how to unlock all of them.

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The final Experiment is the toughest rematch against Sephiroth.

The Hojo’s Laboratory category is one of the more interesting ones in Crisis Core Final Fantasy VII: Reunion as many of the Experiments that you fight are rematches of story bosses but with higher stats and more attacks. Indeed, the final mission in this category is the toughest battle in the game outside of the Minerva superboss.

As a result, unlocking missions in this category works a bit differently than others. Simply completing the preceding missions isn’t enough to unlock the next until you get the final unlock in Chapter 10 which will then make all missions available. The table below will tell you when you can unlock every mission, along with the rewards.

All Hojo’s Laboratory Missions¶

Mission #	Mission Name	Rewards	How to Unlock
5-1-1	Experiment No. 101	Treasure Chest: None, Clear Rewards: Fire materia	Reach Chapter 2
5-1-2	Experiment No. 102	Treasure Chest: None, Clear Rewards: Amulet	Reach Chapter 3
5-1-3	Experiment No. 103	Treasure Chest: None, Clear Rewards: Lightning Ring	Reach Chapter 4
5-1-4	Experiment No. 104	Treasure Chest: None, Clear Rewards: Drain materia	Reach Chapter 5
5-1-5	Experiment No. 105	Treasure Chest: None, Clear Rewards: Venom Shock	Reach Chapter 6
5-1-6	Experiment No. 106	Treasure Chest: Adamantite, Elixir, Clear Rewards: Drainra	Reach Chapter 6
5-2-1	Experiment No. 107	Treasure Chest: None, Clear Rewards: Curaga materia	Reach Chapter 9
5-2-2	Experiment No. 108	Treasure Chest: None, Clear Rewards: Firaga materia	Reach Chapter 9
5-2-3	Experiment No. 109	Treasure Chest: None, Clear Rewards: Mortal Shock	Reach Chapter 10
5-2-4	Experiment No. 110	Treasure Chest: None, Clear Rewards: Wall materia	Clear Mission 5-2-3
5-2-5	Experiment No. 111	Treasure Chest: None, Clear Rewards: Fat Chocobo Feather x4	Clear Mission 5-2-4
5-2-6	Experiment No. 112	Treasure Chest: None, Clear Rewards: Osmose Blade materia	Clear Mission 5-2-5
5-3-1	Experiment No. 113	Treasure Chest: None, Clear Rewards: Poison Aerial materia	Clear Mission 5-2-6
5-3-2	Experiment No. 114	Treasure Chest: None, Clear Rewards: Death Twister materia	Clear Mission 5-3-1
5-3-3	Experiment No. 115	Treasure Chest: None, Clear Rewards: Iron Fist materia	Clear Mission 5-3-2
5-3-4	Experiment No. 116	Treasure Chest: None, Clear Rewards: Platinum Bangle	Clear Mission 5-3-3
5-3-5	Experiment No. 117	Treasure Chest: None, Clear Rewards: Crystal Orb	Clear Mission 5-3-4
5-3-6	Experiment No. 118	Treasure Chest: None, Clear Rewards: Dark Matter x5	Clear Mission 5-3-5
5-4-1	Experiment No. 119	Treasure Chest: None, Clear Rewards: Element Blade materia	Clear Mission 5-3-6
5-4-2	Experiment No. 120	Treasure Chest: None, Clear Rewards: Magical Punch materia	Clear Mission 5-4-1
5-4-3	Experiment No. 121	Treasure Chest: None, Clear Rewards: Flare materia	Clear Mission 5-4-2
5-4-4	Experiment No. 122	Treasure Chest: None, Clear Rewards: Fat Chocobo Feather x5	Clear Mission 5-4-3
5-4-5	Experiment No. 123	Treasure Chest: None, Clear Rewards: Quake materia	Clear Mission 5-4-4
5-4-6	Experiment No. 124	Treasure Chest: None, Clear Rewards: Ribbon	Clear Mission 5-4-5

Of special note with these Experiment missions are the battles against the Zack clones in M5-3-2 and M5-4-5. The final mission in this category, another rematch with Sephiroth, is the toughest battle in the game outside of Minerva, so you’ll want to make sure you have all of the best equipment available before challenging him.