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This Trophy/Achievement will require you to take down 3 enemies with one Detonate Grenade Quickhack. Your first task here is to acquire the Quickhack, so play through the Side Jobs and Hustles until you have enough Perk Points to get intelligence to Level 16. Now purchase the Hacking Overlord Skill and then craft the Detonate Grenade Quickhack.

Finally, equip the Quickhack and play through the Watson Hustles until you find three enemies standig close to each other, then press [L1/LB] on the enemy and activate the quickhack to unlock the Trophy.