Tapeworm is a recurring job that’ll pop up after you complete various Main Jobs, with segments occurring at the end of Automatic Love, Transmission and Life During Wartime. What you say and do during these segments don’t really matter, they’re just there to move the story along.
Finally, however, after you finish the Main Job Search and Destroy, Tapeworm will stop flirting with being a Side Job and will take on more significance - as a proper Main Job you can’t avoid. As soon as you exit the Sunset Motel at the end of the aforementioned Search and Destroy you’ll have a major relic malfunction.
When you wake up you’ll find yourself in Pacifica. Johnny’s been busy while he was in control. Follow him and say what you will, climb through a window, and loot the cache he indicates to obtain Johnny’s Tank Top inner torso armor and some dog tags. After this you’ll end up chatting with Johnny, who makes a promise and asks a favor. Respond how you wish, none of your dialogue choices matter until he starts talking about Rogue and Adam Smasher, at which point he’ll ask to take control of your body for a while. Eventually you’ll get three options:
- “OK, I’ll give you control.”
- “Not gonna happen.”
- “Need to think about it.”
Your choice here actually doesn’t determine anything, your actions do. You can promise to let Johnny have control and never make good on it (instead continuing on with Nocturne Op55N1) or you can decline, then change your mind. Either way, hop back through the window and this job will end, replaced by the Side Job Chippin’ In. Going to Afterlife and progressing the Side Job Chippin’ In is a defacto concession of control to Johnny. It’s also worth noting that while Chippin’ In is a Side Job, it’s incredibly important to the story. Not strictly necessary, but there are two endings that require you to complete Chippin’ In (and subsequent quests) and your relationship with Johnny is greatly affected by what you say and do during Chippin’ In.